Recombinant respiratory syncytial virus from which the entire SH gene has been deleted grows efficiently in cell culture and exhibits site-specific attenuation in the respiratory tract of the mouse
Abstract
The small hydrophobic protein SH of human respiratory syncytial virus (RSV) is a short transmembrane surface protein of unknown function. A full-length cDNA of RSV strain A2 (subgroup A) antigenomic RNA was modified such that the entire SH gene, including the transcription signals and the complete m …
Keywords
Administration
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
RNA
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
Cultured
Antigens
cell line
DNA
polymerase chain reaction
recombination
Inbred BALB C
Base Sequence
Viral
Molecular Sequence Data
Viral Proteins / genetics
cattle
virus replication
viral / immunology
hn protein*
p l collins
blotting
chlorocebus aethiops
vero cells
respiratory syncytial virus
viral proteins / immunology
human / genetics
intranasal
tumor cells
viral / genetics
precipitin tests
northern
viral plaque assay
viral proteins / physiology*
human / growth & development
pmid:9371553
pmc230197
doi:10.1128/jvi.71.12.8973-8982.1997
a bukreyev
s s whitehead
gene deletion
giant cells / virology
messenger
human / physiology*
respiratory system / virology
viral envelope proteins / genetics
viral envelope proteins / physiology*
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Citation
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116735
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