A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers
Abstract
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCN …
Keywords
databases
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
RNA
gene expression regulation
humans
pubmed abstract
nih
national institutes of health
national library of medicine
prognosis
research support
female
N.I.H.
Extramural
Receptors
Organ Specificity
gene expression profiling
genetic predisposition to disease
mutation*
neoplastic
pmid:29622464
pmc5959730
doi:10.1016/j.ccell.2018.03.014
ashton c berger
anil korkut
rehan akbani
breast neoplasms / genetics*
dna copy number variations*
gene regulatory networks*
genital neoplasms
female / genetics*
long noncoding / genetics
estrogen / genetics
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114479
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