Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha
Abstract
Adipocyte differentiation is regulated by at least two major transcription factors, CCAAT/enhancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma). Expression of PPARgamma in fibroblasts converts them to fat-laden cells with an adipocyte-like morph …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Adipocytes / metabolism
enhancer elements
genetic*
pmid:10075691
doi:10.1074/jbc.274.12.7946
A K El-Jack
J K Hamm
S R Farmer
3T3 Cells
Adipocytes / cytology
Adipocytes / drug effects
Biological Transport / drug effects
CCAAT-Enhancer-Binding Proteins
Cell Differentiation / drug effects
DNA-Binding Proteins / metabolism*
Fibroblasts / metabolism
Glucose / metabolism*
Glucose Transporter Type 4
Insulin / pharmacology*
Inbred BALB C
Monosaccharide Transport Proteins / metabolism
Muscle Proteins*
Nuclear Proteins / metabolism*
Receptors
Cytoplasmic and Nuclear / metabolism*
Transcription Factors / metabolism*
Citation
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111771
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