Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression
Abstract
We have constructed a recombinant adenovirus gene delivery system that is capable of undergoing growth phase-dependent site-specific recombination. When propagated in 293 producer cells, the vector retains its linear double-stranded form and can be propagated to high titer and purified by convention …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
gene expression
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
P.H.S.
Cells
Cultured
pmid:11070029
pmc113234
doi:10.1128/jvi.74.23.11296-11303.2000
x wang
w zeng
b seed
adenoviridae / genetics*
enhancer elements
genetic*
gene rearrangement*
gene transfer
horizontal
genetic vectors*
herpesvirus 4
human / genetics*
plasmids
polymerase chain reaction
recombination
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110137
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