Determining the quality of red wine is based on many qualitative and quantitative factors. Compared with other evaluation methods, the cloud model has an uncertainty transformation between a qualitative concept and its corresponding quantitative value, and the uncertainty transformation included fuzziness and randomness, which is suitable for solving the complexity of red wine evaluation. This study introduced the cloud model into quality evaluation of red wine for the first time, and a novel algorithm of comprehensive cloud model was proposed based on an addition algorithm of two cloud models. Furthermore, to validate the cloud model adopted in our red wine evaluation system, we used the gray relational analysis and fuzzy evaluation method. The evaluation result for the red wine sample was Good, and the result confirmed that our cloud model can be used to evaluate the quality of red wine. PRACTICAL APPLICATIONS: In 2013, China surpassed France to become the largest country of red wine consumption in the world. Red wine is made by a natural fermentation process. There are several components that make up red wine, but the most abundant is grape juice. Ethyl alcohol is the second most abundant element and it is made naturally by the fermentation of the sugar in grape. There are more than 1,000 remaining components in the recipe for red wine, where 300 are comparatively important. Although the proportion of these components is not high, they are important factors in determining the quality of red wine. Sensory evaluation is the most common method used to determine the quality of red wine. This work has identified a cloud model that can be used, based on sensory evaluation, to determine the quality of red wine.