Research Article

FPGA-Accelerated Transformer Architecture for Real-Time Electrocardiogram Anomaly Detection in Edge-Computing Biomedical Sensors

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SciMatic J Electr Electron Eng, 2026, 1 (1), 23-30, ISSN

Abstract

Real-time and accurate detection of cardiac anomalies from electrocardiogram (ECG) signals is critical for timely medical intervention, particularly in remote patient monitoring and wearable health devices. Traditional cloud-based deep learning solutions introduce significant latency and privacy concerns, while existing edge-based approaches often sacrifice model complexity and accuracy due to computational constraints. This paper presents an FPGA-accelerated Transformer architecture designed for real-time ECG anomaly detection in edge-computing biomedical sensors. We propose a highly optimized, quantized Transformer model tailored for resource-constrained FPGAs, leveraging custom hardware accelerators for its computationally intensive self-attention and feed-forward layers. Implemented on a Xilinx Zynq UltraScale+ MPSoC, the system processes ECG data from the MIT-BIH Arrhythmia Database, achieving an F1-score of 98.2% for anomaly detection. Our experimental results demonstrate a significant reduction in inference latency to less than 0.8 milliseconds per ECG segment and an energy efficiency improvement of over 15x compared to equivalent CPU/GPU implementations on edge platforms. This work showcases the potential of FPGA-based acceleration to enable sophisticated deep learning models for critical real-time biomedical applications at the edge, fostering advancements in personalized and pervasive healthcare.

Keywords edge computing ecg anomaly detection fpga Transformer
Authors 3

The team behind this paper

3 authors, 3 institutions.

This paper Munich University of Applied Sciences — Germany Munich University of Ap… 1 author Tokyo Institute of Technology — Japan Tokyo Institute of Tech… 1 author University of Ghana — Ghana University of Ghana 1 author Prof. Elena Rostova — corresponding author ER Prof. Elena Rostova ✉ Dr. Hiroshi Tanaka HT Dr. Hiroshi Tanaka Dr. Amara Kwame AK Dr. Amara Kwame

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Bibliographic Information

Prof. Elena Rostova, Dr. Hiroshi Tanaka, Dr. Amara Kwame, (2026). FPGA-Accelerated Transformer Architecture for Real-Time Electrocardiogram Anomaly Detection in Edge-Computing Biomedical Sensors, SciMatic Journal of Electrical and Electronics Engineering, 1(1): 23-30
Bibtex Citation
@article{prof._elena_rostova2026sjeee,
author = {Prof. Elena Rostova and Dr. Hiroshi Tanaka and Dr. Amara Kwame},
title = {FPGA-Accelerated Transformer Architecture for Real-Time Electrocardiogram Anomaly Detection in Edge-Computing Biomedical Sensors},
journal = {SciMatic Journal of Electrical and Electronics Engineering},
year = {2026},
volume = {1},
number = {1},
pages = {23-30},
doi = {},
url = {https://scimatic.org/show_manuscript/9141}
}
APA Citation
Rostova, P.E., Tanaka, D.H., Kwame, D.A., (2026). FPGA-Accelerated Transformer Architecture for Real-Time Electrocardiogram Anomaly Detection in Edge-Computing Biomedical Sensors. SciMatic Journal of Electrical and Electronics Engineering, 1(1), 23-30. https://doi.org/

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