Nickel(II) metal-organic framework (Ni-MOF) was used as an efficient catalyst for the synthesis of 2-aryl benzimidazole and benzothiazole derivatives. Ni-MOF was prepared using nickel(II) nitrate hexahydrate and 4,4'- diaminodiphenyl sulfone (DDS), then characterized via XRD, FE-SEM, EDX, FT-IR, BET, and TGA/DTG. The catalyst was then used in the synthesis of some benzimidazole and benzothiazole derivatives. It was found to be an efficient method for the preparation of 2-aryl benzimidazole and benzothiazole derivatives in good to excellent yields at room temperature. The catalyst was easily recovered and reused five times without substantial loss in activity. This procedure has further advantages including mild and environmentally benign conditions, easy workup, simple procedure, high yields, recyclability and nontoxicity of the catalyst.