The fashion industry is one of the largest markets for illegal wildlife products. This study examined US luxury fashion-related wildlife seizures made between 2003 and 2013 to better guide detection, enforcement, and policy. The findings of this study indicate that the number of incidents has increased over the 11-year period, while the number of associated items seized has decreased over this time. Of these seizures, nearly 88% were produced goods. A small proportion of genera made up the majority of seizures, with reptiles in particular accounting for 84% of incidents. Over half of all wildlife was wild-caught and was exported from eight countries. Based on these findings, it is suggested that policy be enacted relating specifically to the use of exotic leathers and furs, and that situational crime prevention alongside commitments to sustainability from fashion brands be used to reduce illegal imports and improve industry sustainability.