Evidence for Bell's nonlocality is so far mainly restricted to microscopic systems, where the elements of reality that are negated predetermine results of measurements to within one spin unit. Any observed nonlocal effect (or lack of classical predetermination) is then limited to no more than the difference of a single photon or electron being detected or not (at a given detector). In this paper, we analyze experiments that report the Einstein-Podolsky-Rosen (EPR) steering form of nonlocality for mesoscopic photonic or Bose-Einstein condensate systems. Using an EPR steering parameter, we show how the EPR nonlocalities involved can be quantified for four-mode states, to give evidence of EPR-nonlocal effects corresponding to a two-mode number difference of 10^{5} photons, or of several tens of atoms (at a given site). Applying to experiments, we also show how the variance criterion of Duan, Giedke, Cirac and Zoller for EPR entanglement can be used to determine a lower bound on the number of particles in a pure two-mode EPR-entangled or steerable state.