Copper-catalyzed enantioselective alkynylation of pyrazole-4,5-diones with terminal alkynes.
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Copper-catalyzed enantioselective alkynylation of pyrazole-4,5-diones with terminal alkynes.

Lu, Jian;Luo, Ling-Shan;Sha, Feng;Li, Qiong;Wu, Xin-Yan;
Chemical communications (Cambridge, England) 2019 Vol. 55 pp. 11603-11606
226
lu2019coppercatalyzedchemical

Abstract

A copper-catalyzed enantioselective alkynylation between terminal alkynes and pyrazole-4,5-diones has been developed. With 2.5 mol% CuI and 3 mol% chiral ligand L15, chiral propargylic alcohols bearing a pyrazolone motif were produced in 82-99% yield and up to 98% ee. Moreover, both enantiomers of the chiral propargylic alcohols were obtained with ligands L12 and L15, respectively.

Keywords

uplc-ms/ms monosaccharide composition polyporus umbellatus polysaccharide pre-column derivation

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DOI:
10.1039/c9cc05252f

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