The present study investigates and evaluates the antioxidant and antithrombotic effects of Dendropanax morbifera Léveille (Araliaceae) extracts (DME) and its ferment (FDME). Antioxidant activities were improved by FDME treatment, especially 66.74% of hydroxyl radical scavenging activity was observed at 100 μg of FDME treatment. In vitro antithrombotic activity was also improved by accelerated fibrinolysis and blood clot degradation as well as prolonged prothrombin time. Similar to those results, in vivo experiment also showed that the formation of thrombus was alleviated and paralysis or death due to thromboembolism was also prevented to some extent. PRACTICAL APPLICATIONS: A bioprocessing technology, fermentation is known to enhance nutritional qualities which has beneficial effects on health by improving antioxidant activity, lipid levels, and antithrombotic activities. DME, healthy food source has been known to have a potential for improving blood circulation improvement. The present study provides beneficial information on the potential and excellence of the antithrombotic efficacy of DME and FDME. The present results elucidate the antithrombotic activities of DME and FDME, which is useful in the development of new food materials for cardiovascular health and new antithrombotic agents for clinical application.