To examine the relationship between several e-cigarette-related characteristics and daily e-cigarette use among adolescent current users.Secondary analysis of 2016 National Youth Tobacco Survey data.United States middle schools and high schools.One thousand five hundred seventy-nine current e-cigarette users.Daily e-cigarette use and e-cigarette flavors, brands, device type, and acquisition were measured.Logistic regression and Poisson regression models were built.A total of 13.6% of current users reported daily use. Results indicated that daily users were at increased odds of using all flavor types (all P < .001), with the exception of menthol/mint, and using a higher number of flavors than nondaily users ( P < .001). Daily users were more likely to use Blu, eGo, Logic, Halo, NJOY, and another unlisted brand but less likely to report they did not know the brand used (all P ≤ .01). Daily users also reported using a higher number of brands than nondaily users ( P < .001). Daily users were at increased odds of using marijuana/tetrahydrocannabinol (THC) oil wax as device ingredients ( P < .001) and less likely to use only nicotine ( P < .001) or unknown ingredients ( P = .004). Daily users were more likely to acquire e-cigarettes from a vape shop, gas station/convenience store, Internet, mall/shopping center kiosk, drug store, grocery store, or other place (all P ≤ .01).Comprehensive efforts are needed to reduce e-cigarette use and nicotine addiction among adolescents.