Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons
Abstract
Circulating ghrelin is decreased in obesity, and peripheral ghrelin does not induce food intake in obese mice. We investigated whether ghrelin resistance was a centrally mediated phenomenon involving dysregulated neuropeptide Y (NPY) and agouti-related peptide (AgRP) circuits. We show that diet-indu …
Keywords
diet
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
Inbred C57BL
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
cognition / drug effects
neurons / metabolism
obesity / complications
obesity / blood
obesity / metabolism*
eating / physiology
eating / drug effects
neuropeptide y / metabolism*
obese
goats
growth hormone / metabolism
zane b andrews
agouti-related protein / metabolism*
ghrelin / genetics
ghrelin / metabolism*
ghrelin / pharmacology
pmid:20826561
doi:10.1210/en.2010-0556
dana i briggs
pablo j enriori
arcuate nucleus of hypothalamus / metabolism*
cognition / physiology
atherogenic
drug resistance* / physiology
ghrelin / blood
obesity / etiology
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274239
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