Granulocyte-macrophage colony-stimulating factor and interferon-gamma prevent dexamethasone-induced immunosuppression of antifungal monocyte activity against Aspergillus fumigatus hyphae
Abstract
Treatment with corticosteroids is an important risk factor for development of invasive aspergillosis. We evaluated the effect of dexamethasone (DEX) on superoxide anion (O2-) release and damage caused by elutriated human monocytes (EHM) on unopsonized hyphae of Aspergillus fumigatus. In addition, we …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
humans
pubmed abstract
nih
national institutes of health
national library of medicine
adult
immunosuppression
glucocorticoids / adverse effects
monocytes / microbiology
monocytes / metabolism
granulocyte-macrophage colony-stimulating factor / pharmacology*
monocytes / drug effects*
aspergillus fumigatus / drug effects*
e roilides
t j walsh
interferon-gamma / pharmacology*
aspergillus fumigatus / growth & development
dexamethasone / adverse effects
pmid:8786473
c blake
aspergillosis* / metabolism
aspergillosis* / microbiology
dexamethasone / antagonists & inhibitors*
glucocorticoids / antagonists & inhibitors*
superoxides / metabolism*
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