Objectives: The objective of this study was to comparethe effects of Propofol 1%, Propofol 2%, Ketamine, Pentothal,Etomidate and Etomidate-lipuro on venous endothelium.Materials and methods: The study was done fromAugust 2007 to May 2008 after approval of Faculty’sEthic Committee. Forty rabbits were obtained. Propofol1% (n=6), Propofol 2% (n=6), Ketamin (n=6), Penthotal(n=6), Etomidate (n=6), Etomidate lipuro (n=6) and normalsaline (Control Group, n=4) was given 1 cc via externaljugular vein. After 5 minutes from the injenction 6species 2 mm in length segments were taken from theinjencted veins. Species were fixed in 4˚C gluteraldehydethan postfixed in 4°C osmium tetroxide. Visualisation wasperformed with scanning electron microscope.Results: In Propofol 1 %, Propofol 2% and Penthotalgroups normal endothelial structures were observed. InEtomidate group damage of the endothelial cells were observedsignificantly compared with control. In Etomidatelipuro group minimal deformation was observed comparedto control.Conclusion: Etomidat causes significant endothelial deformation,moreover lipuro minimalises these effects. Inorder to need to use etomidate for general anesthesia,for less pain during injection depending on vascular injurylipuro form would be more appropriate. However, furtherstudy is required. J Clin Exp Invest 2011; 3(2): 164-167