Concerns of infectious disease outbreaks have recently reached the forefront of global security issues and resulted in new engagements among foreign science advisors, host country scientists, and officials. There are lessons to be learned from the numerous organizations working in global regions of endemic disease who are building capacity to survey pathogens and prevent and contain epidemics. Working with foreign scientists, health professionals, and administrators can be challenging; building partnerships based on respect and mutual trust is key to achieve effective change. Engendering ownership, working towards mutual success, paying close attention to cultural norms and the local regulatory climate, close collaboration with other stakeholders, and imaginative problem solving all contribute to mission success.