Aim: The present study was designed to assess the effect of standardized proanthocyanidin on postprandial blood glucose level after maltose load in non diabetic females. Materials and Methods: Single oral dose (50 mg) of proanthocyanidin tablet was administered by non diabetic adult females thirty minutes before oral ingestion of maltose load (50 gm) using acarbose as comparator. Blood glucose was monitored before and 15, 30, 60, 120, and 180 min post ingestion of maltose. Results: The results showed considerable decrease in 30 and 60 min postprandial hyperglycemia due to the use of proanthocyanidin, while non significant decrease of AUC and delta AUC was obtained in both proanthocyanidin and acarbose groups compared with control. However, comparable results for 2 hr postprandial hyperglycemia were achieved by proanthocyanidin (41%) and acarbose (40%). Conclusion: single oral dose of proanthocyanidin attenuates hyperglycemia after maltose challenge in non-diabetic females and such effect was comparable to that produced by acarbose. [J Intercult Ethnopharmacol 2013; 2(1.000): 43-48]