Following the design of a conservation-based agricultural development strategy and food security strategy, the Tigray government has implemented different pro-poor development programs over the past years to address the problems of food security. This study attempts to investigate the effectiveness of government policy interventions at different scales addressed to improve food security. Food security both at the regional and district level was investigated by deriving food balance sheets for the period 2000-2008. An empirical analysis based on a logit model was also employed to analyze household level food security status. The results of the logit model reveal that government policy interventions such as water harvesting schemes, employment generation schemes, and promotion of technology adoption significantly contribute to a higher likelihood of household food security status. The findings of the food balance sheet also indicate that the region has made some impressive development gains in improving regional food self-sufficiency, indicating the importance of government interventions in improving food security both at the household and regional level.