solvent-free synthesis and oxidative aromatization of diethyl-2,6-dimethyl-4-(1-phenyl-3-aryl-1h-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylates using hypervalent iodine (iii) reagents

solvent-free synthesis and oxidative aromatization of diethyl-2,6-dimethyl-4-(1-phenyl-3-aryl-1h-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylates using hypervalent iodine (iii) reagents

;Parvin Kumar;Khalid Hussain;Ashwani Kumar
proceedings - 2018 4th international conference on computing, engineering, and design, icced 2018 2014 Vol. 3 pp. 75-84
285
kumar2014currentsolvent-free

Abstract

In this article, an efficient, environmentally benign, solvent-free synthesis of diethyl-2,6-dimethyl-4-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-1,4-dihydropyridine-3,5-dicarboxylates and their simple oxidative aromatization in presence of selected hypervalent iodine (III) reagents under solvent-free condition at room temperature is demonstrated. All reactions were carried out by grinding the reactant pyrazole substituted Hantzch-1,4-dihydropyridines and hypervalent iodine (III) reagent in a mortar with pestle. [Hydroxy(tosyloxy)iodo]benzene act as an more efficient oxidizing reagent in comparison to phenyliodine bistrifluoroacetate and iodobenzene diacetate in terms of reaction time and yields. The advantages of present protocol are the environment friendly, short reaction time, mild reaction conditions, and high yields of the products.

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0x95644003c57E6F55A65596E3D9Eac6813e3566dA
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196200
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10.5267/j.ccl.2014.1.002
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