This study aimed to evaluate the influence of the climatology of the semi-arid from Alagoas-Brazil on the raw milk microbiota in semi-arid area of the 07 micro-regions of the State of Alagoas of Alagoas, Brazil. The climatic data were extracted from National Institute of Meteorology from the Brazilian government. The raw milk was collected after the dairy cow milking process in 12 small rural associations of the semi-arid from the State of Alagoas, during the 4 seasons and the raw milk was carried out procedures of sampling, transportation and microbiological analysis. A total of 58 samples were counted coliforms at 45°C, Escherichia coli and coagulase-positive Staphylococcus. Only 02 rural associations presented low levels of microbiological contamination, which were located in areas of climatic conditions and parameters of thermal comfort index and vegetation index favorable, but 10 rural associations presented high counting of coliforms at 45°C, Escherichia coli. The climatologic parameters (maximum temperature, atmospheric pressure), bovine comfort thermal index and vegetation index have showed to influence the growth of the coliforms at 45°C and Escherichia coli with high incidence during the summer weather. The precipitation parameter, bovine thermal comfort and vegetation index have displayed to influence coagulase-positive Staphylococcus counting especially during the period between the summer end and the autumn beginning seasons. New Actions, and Rural Education and Health Programs should be implemented as politics of Food Safety. New strategies and programs for dissemination more effective on the risks of transmission of pathogens and Foodborne Diseases are necessary as the part of emergence politics of the health and education areas. Regulatory Actions should be encouraged within the processes that improve the quality control of raw milk as well its bioproducts, with professional assistance relevant in agriculture area.