The determinant factor of poverty is a complex and multidimensional problem which is related to social, economic, cultural and other aspects, which is a phenomenal problem in the world, including Indonesia which is a developing country. This study aims to determine the influence and relationship of economic growth, inflation, HDI, gini ratio, and dependency ratio to the level of poverty in Indonesia. This research was conducted in Indonesia. The data were collectied thorugh literature review.Secondary data (panel data) collected relating to economic growth, HDI, inflation, gini ratio, and dependency ratio period 2005-2015. Data were analyzed descriptively and quantitative measure. The study indicates that based on functional relationship the quality of human resources has a larger influence than the economic growth on the decrease of poverty. The data were analiysed descriptively in quantitative measure. The results showed that based on the functional relationship in which the Economy growth had positive effect and the significance level of 20% to poverty, the HDI had a negative effect but not significant . Inflation was negative effect and significant, gini ratio had negative effect and significant, dependency ratio,had positive effect but not significant to poverty reduction. The study is an academic study and limited only to analysis of the inpact of economic growth, HDI, gini ratio inflation and dependency ratio on the level poverty.