Brain damage due to episodic alcohol exposure in vivo and in vitro: furosemide neuroprotection implicates edema-based mechanism
Abstract
Adult rats intubated with a single dose of ethanol (alcohol; approximately 5 g/kg) for 5 to 10 successive days incur neurodegeneration in the entorhinal cortex, dentate gyrus, and olfactory bulbs accompanied by cerebrocortical edema and electrolyte (Na+, K+) accumulation. The brain damage is not les …
Keywords
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
animals
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
male
Alcoholic Intoxication / pathology*
Ethanol / toxicity*
Rats
Sprague-Dawley
Organ Specificity
pmid:9472987
doi:10.1096/fasebj.12.2.221
m a collins
j y zou
e j neafsey
alcoholic intoxication / complications
alcoholic intoxication / metabolism
brain / drug effects
brain / metabolism
brain / pathology*
brain edema / etiology
brain edema / pathology
dentate gyrus / pathology
diuretics / pharmacology
dizocilpine maleate / pharmacology
entorhinal cortex / pathology
excitatory amino acid antagonists / pharmacology
furosemide / pharmacology*
nerve degeneration / etiology
nerve degeneration / pathology*
neuroprotective agents*
olfactory bulb / pathology
organ culture techniques
potassium / metabolism
sodium / metabolism
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110733
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