Identification of T-cell epitopes binding to MHC class II molecules is an important step in epitope-based vaccine development. This process has since been accelerated with the use of bioinformatics tools to aid in the prediction of peptide binding to MHC class II molecules and also to systematically scan for candidate peptides in antigenic proteins. There have been many prediction software developed over the years using various methods and algorithms and they are becoming increasingly sophisticated. Here, we illustrate the use of machine learning algorithms to train on MHC class II peptide data represented by feature vectors describing their amino acid physicochemical properties. The developed prediction model can then be used to predict new peptide data.