This paper presents the basin approach to the design, development, and operation of a hydrological forecasting and early warning system in a large transboundary river basin of high flood potential, where accurate, reliable, and timely available daily water-level and reservoir-inflow forecasts are essential for water-related economic and social activities (the Amur River basin case study). Key aspects of basin-scale system planning and implementation are considered, from choosing efficient forecast models and techniques, to developing and operating data-management procedures, to disseminating operational forecasts using web-GIS. The latter, making the relevant forecast data available in real time (via Internet), visual, and well interpretable, serves as a good tool for raising awareness of possible floods in a large region with transport and industrial hubs located alongside the Amur River (Khabarovsk, Komsomolsk-on-Amur).