Exotic species introductions are a global phenomenon and protected areas are susceptible to them. Understanding the drivers of exotic species richness is vital for prioritizing natural resource management, particularly in developing countries with limited resources. We analyzed the influence of coarse resolution factors on exotic species richness (plants, mammals, and birds) in Argentina’s National Parks System. We collected data on native species richness, year of park formation, park area, region, elevation range, number of rivers crossing area boundaries, roads entering area, mean annual rainfall, mean annual temperature, mean annual number of visitors, and Human Influence Index within and surrounding each park. We compiled 1,688 exotic records in 36 protected areas: 83% plants and 17% animals (9.5% mammals, 5.5% birds, 1.5% fishes, 0% amphibians, 0% reptiles). The five parks with the most exotic species (all taxa combined) were in north Patagonia. Exotic grasses were the most common exotic plants, and within animals, lagomorphs and feral ungulates were remarkably widespread. Exotic plant richness was mostly influenced by temperature and native plant richness, while exotic mammal and bird richness was driven mostly by anthropogenic variables, with models explaining 36–45% of data deviance. Most variables that positively influenced exotic taxa were indirectly related to an increase in spatial heterogeneity (natural or anthropogenic), suggesting greater niche space variability as facilitators of exotic richness increase. Additional data are needed to further investigate the patterns and mechanisms of exotic species richness in protected areas, which will help to prioritize the greatest needs of monitoring and management.