Although endometrial cancer (EC) is often diagnosed at an early curable stage, the incidence and mortality from EC is rising and minority women are particularly at risk. We hypothesize that delays in clinical presentation contribute to racial disparities in EC mortality and treatment related morbidity. Improved methods for EC risk assessment and distinguishing abnormal uterine bleeding and postmenopausal bleeding from physiological variation are needed. Accordingly, we propose a multi-pronged strategy that combines innovative patient education with novel early detection strategies to reduce health impacts of EC and its precursors, especially among Black women. Futuristic approaches using gamification, smartphone apps, artificial intelligence, and health promotion outside of the physical clinic hold promise in preventing EC and reducing morbidity and mortality related to the disease, but they also raise a number of questions that will need to be addressed by future research.