The present study was aimed to investigate the lung functions and health-related quality of life (HRQoL) of garbage collection workers of the urban cities in India.Urban city in India.The cross-sectional study encompassed 110 participants, 55 garbage collection workers in a garbage depot in the urban city of India and 55 age-matched control group volunteering to participate in the study. Assessment of the lung function was done by using computerized spirometry and HRQoL with the World Health Organization Quality of Life-BREF (WHOQOL-BREF) questionnaire.Various statistical measures such as mean, standard deviations (SD), test of significance were utilized to analyze the data. Parametric data were analyzed by unpaired -test and nonparametric data by Mann-Whitney U test.A statistically significant difference was seen in the lung functions and quality of life in garbage collection workers except for the psychological component of WHOQoL-BREF questionnaire.The study concludes that there is a greater impairment in the lung functions of garbage collection workers as compared to that of normal individuals. Moreover, the quality of life is lower in garbage workers than that of normal individuals considering the physical, social, and environmental aspects.