A symptomatic patient with atrial fibrillation and Cheyne-Stokes respiration (CSR) was implanted with a transvenous phrenic nerve stimulation (TPNS) device - the remedē System - that is indicated for adult patients with moderate to severe central sleep apnea. Sleep recordings demonstrated that TPNS eliminated periodic breathing by activating the diaphragm and stabilizing respiratory patterns. These recordings of pre-programmed TPNS on versus off illustrate prompt (a) stabilization of tidal airflow, respiratory effort and oxygenation as stimulation amplitude increased stepwise, and (b) recurrence of CSR immediately after TPNS deactivated. Despite differences in respiratory patterns, minute ventilation was comparable during periods on and off TPNS. These findings suggest that diaphragmatic pacing entrains ventilation without disrupting sleep, accounting for observed improvements in periodic breathing, gas exchange, sleep architecture and quality of life. Effective means to relieve CSR could potentially mitigate nocturnal cardiovascular stress and disease progression.