TransFORmation of IndiGEnous PrimAry HEAlthcare Delivery (FORGE AHEAD) partnered with local clinical and community teams in 11 First Nations (FN) communities across Canada to develop quality improvement (QI) initiatives aimed at improving T2DM.Pre-post mixed-methods case study design was used. The 18-month intervention included community and clinical readiness, development of a community diabetes registry and clinical system, and QI activities. Participants consisted of community members, 18 yrs and older, with diabetes. Changes in clinical outcomes and clinical practice guideline (CPG) recommendations were assessed pre and post intervention using multilevel regression (patients nested within communities) adjusted forindividual andcommunity baseline characteristics.No significant change in HbA1c orsBP, but a small reduction indBP(-0.75mmHg, p<0.05) and LDL (-0.09mmol/L, p<0.05) was observed in 2008 adults with T2DM (mean age: 60·5 (SD:14·6) years; female: 57·2%). Individuals not at CPG targets at baseline had significant reductions in: %HbA1c (N=616): -0.40 (95%CI:-0·55,-0·24),sBP (N=561): -7·67mmHg (95%CI:-9·23, -5·72),dBP (N=291): -7·46mmHg (95%CI:-8·69,-6·26), LDL (N=450): -0·37mmo/l (95%CI:-0·44, -0·29).Annual HbA1c (OR:1·95; 95%CI:1·66, 2·29), BP (OR:1·78; 95%CI:1·52, 2·09), LDL (OR:1·27; 95%CI:1·10, 1·47) and CKD screening (OR:6·37; 95%CI:5·16, 7·92)increased but retinopathy screening decreased (OR:0·68; 95%CI:0·57, 0·82). No significant change in foot exams (OR:0·97; 95%CI:0·76, 1·23) or BMI recordings (OR:0·96; 95%CI:0·82, 1·12) was seen. Overall, individualsweremorelikely to receive ≥ 75% of CPG recommended services compared to baseline (OR:1·51; 95%CI:1·27, 1·80).FORGE AHEAD is the first Canadian study to demonstrate that a FN community-led QI intervention can lead to diabetes improvements.