Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection
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Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

Ibler, Angela E. M.;ElGhazaly, Mohamed;Naylor, Kathryn L.;Bulgakova, Natalia A.;El-Khamisy, Sherif F.;Humphreys, Daniel;
Nature communications 2019 Vol. 10 pp. 1-14
318
ibler2019typhoidnature

Abstract

Salmonella Typhi produces the typhoid toxin, which damages host cell DNA. Here, Ibler et al. show that the toxin induces a non-canonical DNA damage response mediated by the RPA pathway that drives host cell senescence and facilitates infection.

Keywords

Microbiology Pharmacy and materia medica Biology (General) Medicine Science Immunologic diseases. Allergy public aspects of medicine

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