This study makes use of tannery waste to produce biodiesel using a nano-sulfated zirconia catalyst (ferric-manganese-doped sulfated zirconia). It was through a modified wetness impregnation method that the catalyst was prepared which was then characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FTIR). The catalytic property of the synthesized catalyst was determined by using it to produce biodiesel from tannery waste sheep fat. A study was carried out to find the effect of the different parameters affecting the process. Optimized conditions of 15:1 methanol to fat molar ratio and catalytic loading of 8 wt% at 65 °C with a stirring rate of 400 rpm for a reaction duration of 300 min gave a maximum yield of 98.7 wt%. The performance of the catalyst during recycling was analyzed by conducting reusability study. The reused catalyst gives a maximum yield above 90 wt% up to five cycles with a catalyst recovery of 88 wt%. ASTM D6751 standard was used to compare the analyzed fuel properties of the biodiesel.