This is a lightly edited version of Roger Lewis' notes for the speech he gave at the 11th International Conference on the Reduction of Drug Related Harm in Jersey in March 2000, shortly before his death. In this paper Roger Lewis argues for the need to take global and historical view of both drug markets and ways that nations try to control them. Drug markets have become globalised, influenced by changes in communication, finance, commodity and labour markets. Drug control activities are used to defend global strategic interests, amd foreign policy imperatives usually take precendence over drug policy.