In field trials in was investigated, if the use of the in Germany new active ingredient imazamox enlarge the possibilities of post emergence weed control in soybeans. Furthermore new herbicide strategies were tested on efficacy and selectivity in soybeans. The use of imazamox was very selective and showed a relative broad spectrum of controlled weed species. However, efficacy of imazamox must be supported by a pre-emergence treatment and in most cases by a tank mix partner. For example cleavers (Galium aparine) can not be controlled by imazamox. Tankmixtures of imazamox and bentazon indicated an antagonism. Efficacy to some weed species was reduced compared to solo application. The low dose concept – three applications of low doses at cotyledon stage of weeds led to some success. However, these strategies must be further investigated, before they can be recommended to commercial farming practice. All herbicide strategies tested showed some surviving weed species. This indicates that choice of herbicides, dose rates and application strategies must be done very careful and site specific.