This study was intended to evaluate the various predisposing factors and to assess the causative microorganisms responsible for fascial space infections.A total of 124 patients who reported with an orofacial space infection of odontogenic origin were included. Following thorough evaluation, using a disposable syringe, pus sample was obtained and sent for culture and sensitivity test. Offending teeth were extracted under antibiotic coverage, and incision and drainage was done as and when indicated.The results of this study show that submandibular space (34.6%) is the frequently involved fascial space. Majority of the patients are in the second and third decade of life (46.7%). Staphylococcus species (43.7%) is the most commonly isolated microorganism. Majority of the subject gives a history of hot fomentation (64.5%). Penicillin remains to be the drug of choice. Extraction of the offending tooth under antibiotic coverage and incision and drainage as indicated remains to be treatment option when the scenario is tackled in the initial stages.Since the study was conducted in a semi-urban/rural setup, poor oral hygiene and lack of awareness for the dental health in addition to the delay in reporting to the clinician may have been the causes for the development of such fascial space infections from a small carious tooth.