This study presents an analysis of high-resolution space borne retrievals of the column-averaged dry-air mole fraction of carbon dioxide [Formula: see text] and the role of vegetation in controlling atmospheric CO dynamics over the Indian region. Nadir and glint mode [Formula: see text] retrievals from the Orbiting Carbon Observatory-2 (OCO-2) spectrometer for the period September 2014-July 2017 are studied with satellite-derived normalized difference vegetation index (NDVI) and rainfall over different land cover types. The atmospheric [Formula: see text] variability shows a strong negative correlation with satellite-derived NDVI. Higher rainfall favours the vegetative growth and photosynthetic activity, thus lowers atmospheric [Formula: see text] concentration. The mean monthly [Formula: see text] over terrestrial region of India is observed as 400.18 ± 3.85 ppm with seasonal variations over different land cover types. The correlation of [Formula: see text] with NDVI over mixed forest and deciduous broadleaf forest types was estimated as - 0.86, - 0.76 (p < 0.01), respectively. The study could also highlight strong seasonal [Formula: see text] variability at higher latitudinal zones of India. It is significant to note that space-based observations indicate that atmospheric carbon dioxide levels have surpassed a significant milestone of 400 ppm in recent times. The study provides significant inputs towards improving our understanding of terrestrial biogeochemical carbon cycle over India.