Salmonella remains one of the most common foodborne pathogens worldwide, and its resistance to antimicrobials and disinfectants has increased considerably over the years. Thus, monitoring its resistance to products commonly used in swine production is indispensable for the development of strategies to reduce the occurrence of bacterial resistance. In this context, our aim was to detect Salmonella at different points in swine slaughterhouses, identify the main serotypes, and evaluate their resistance to disinfectants and antimicrobials used in swine production. Salmonella at the processing plants was detected by conventional microbiology. Salmonella strains were tested for susceptibility to peracetic acid (0.5% and 1%), quaternary ammonium (0.5%), and seven antimicrobials. Twenty-eight percent of the samples were positive for Salmonella, with the most identified serotypes being Salmonella Derby, Salmonella Typhimurium, and monophasic Salmonella Typhimurium. All tested strains were susceptible to both concentrations of peracetic acid, but only 28% were susceptible to quaternary ammonium. Sixteen percent of the strains were susceptible to all tested antimicrobials. Only enrofloxacin was efficient in inhibiting the growth of all strains. The highest number of non-susceptible strains was to amoxicillin, followed by chloramphenicol, florfenicol, and doxycycline. Thirty-six percent of the strains were classified as multidrug-resistant. Salmonella were detected in all slaughtering processes, and important serotypes were recovered, including Salmonella Typhimurium, Salmonella Derby, monophasic Salmonella Typhimurium, and Salmonella Infantis. We observed high rates of resistance to quaternary ammonium and to important antimicrobial agents. Salmonella Typhimurium and Salmonella Infantis were the most resistant serotypes.