To estimate an accurate level of IL-8 in aqueous humor among open-angle glaucoma (OAG) patients.Meta-analysis was performed from available studies that investigated the IL-8 level in the aqueous humor of OAG patients and control subjects.A total of 17 studies were selected. The pooled result showed that IL-8 levels in aqueous humor of patients with OAG were higher than in control subjects (SMD=0.98, 95% CI=0.68-1.27, p<0.00001).This meta-analysis indicates that patients with OAG may have a higher aqueous humor IL-8 levels compared to control subjects, which supports the notion that IL-8 is one of the contributing factors in the development of OAG.