Objective: This study was to evaluate a possible accelerating activity of the bone repair process through the use platelet-rich plasma (PRP), associated to biomaterials in sockets produced in cranial skull of dogs. Method: Six animals of indefinite race has been selected, females, approach weight of 8 kg, being carried through six sockets of 8 mm with trefine drill that had been divided in six groups: each group it filled with the following materials: Group I: blood (control group); Group II: blood and PRP; Group III: Biogran® (bioactive glass) and blood; Group IV: Biogran®, blood and PRP; Group V: Bio-Oss® (natural hidroxiapatite of bovine origin) and blood; Group VI: Bio-Oss®, blood and PRP. Thirty and sixty days after procedure the animals had sacrificed themselves and the parts had been fixed in formol 10%, demineralized in EDTA solution, processed and follow to Hematoxilin and Eosin (HE) technique. Results: It did not have significant difference between the control groups (Groups I and II). To the 30 days, it had development of the hard tissue repair, however, if it did not observe significant differences between the two biomaterials (Biogran and Bio-Oss). In 60 days, was observed a bone is in mature state, however, if it microscopically did not evidence significant differences between the use or not of the PRP influencing in the tissue repairing. Conclusion: Carried through the microscopical analysis, concluded that the materials had presented osteoconduction property and absence of inflammatory reaction. The presence or not of PRP did not intervene with the evolution of the repair and is necessity the continuity of new scientific inquiries involving the PRP and its applications.