A simulated environment for early development stages of reinforcement learning algorithms for closed-loop deep brain stimulation.

A simulated environment for early development stages of reinforcement learning algorithms for closed-loop deep brain stimulation.

Castano-Candamil, Sebastian;Vaihinger, Mara;Tangermann, Michael;
conference proceedings : annual international conference of the ieee engineering in medicine and biology society ieee engineering in medicine and biology society annual conference 2019 Vol. 2019 pp. 2900-2904
250
castanocandamil2019aconference

Abstract

In recent years, closed-loop adaptive deep brain stimulation (aDBS) for Parkinson's disease (PD) has gained focus in the research community, due to promising proof-of-concept studies showing its suitability for improving DBS therapy and ameliorating related side effects.The main challenges faced in the aDBS control problem is the presence of non-stationary/non-linear dynamics and the heterogeneity of PD's phenotype, making the exploration of data-driven dynamics-aware control algorithms a promising research direction. However, due to the severe safety constraints related to working with patients, aDBS is a sensitive research field that requires surrogate development platforms with growing complexity, as novel control algorithms are validated.With our current contribution, we propose the characterization and categorization of non-stationary dynamics found in the aDBS problem. We show how knowledge about these dynamics can be embedded in a surrogate simulation environment, which has been designed to support early development stages of aDBS control strategies, specifically those based on reinforcement learning (RL) algorithms. Finally, we present a comparison of representative RL methods designed to cope with the type of non-stationary dynamics found in aDBS.To allow reproducibility and encourage adoption of our approach, the source code of the developed methods and simulation environment are made available online.

Citation

ID: 87013
Ref Key: castanocandamil2019aconference
Use this key to autocite in SciMatic or Thesis Manager

References

Blockchain Verification

Account:
NFT Contract Address:
0x95644003c57E6F55A65596E3D9Eac6813e3566dA
Article ID:
87013
Unique Identifier:
10.1109/EMBC.2019.8857533
Network:
Scimatic Chain (ID: 481)
Loading...
Blockchain Readiness Checklist
Authors
Abstract
Journal Name
Year
Title
5/5
Creates 1,000,000 NFT tokens for this article
Token Features:
  • ERC-1155 Standard NFT
  • 1 Million Supply per Article
  • Transferable via MetaMask
  • Permanent Blockchain Record
Blockchain QR Code
Scan with Saymatik Web3.0 Wallet

Saymatik Web3.0 Wallet