The purpose of conducting this study was to examine the effectiveness of a biopsychosocial-spiritual model in the management of symptoms of a diabetic patient. A 38-year-old female diagnosed with diabetes complained of bouts of sadness and fatigue, a reduced interaction with others, difficulty in falling asleep, felt irritable and experienced severe pain in the joints. The Siddique Shah Depression scale was used to assess her in a semistructured interview with a subjective rating in which she scored a depression of 293.83 (F06.31) due to diabetes. A total number of 11 sessions were held with her during the implementation phase of the intervention plan. A post assessment was carried out and from the pre and post rating on Siddique Shah Depression Scale, it was evident that her overall symptoms had improvement by 33%. Current study highlights the effec tiveness of a biopsychosocial-spiritual treatment approach for managing symptoms associated with diabetes.