Genetic polymorphisms of exon 1 of MBL2 contribute to tuberculosis risk especially in Asian populations: an updated meta-analysis of 26 studies Yu-jiao Wu,1,* Xin Yang,2,* Ting-di Chen,3 Zhi-xin Zhang,4 Yi-zhong You,5 Zheng-da Fan1 1Department of Pharmacy, The Third People’s Hospital, Changzhou, China; 2Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, China; 3Department of Science and Education, The Third People’s Hospital, Changzhou, China; 4Department of Pulmonary Tuberculosis, The Third People’s Hospital, Changzhou, China; 5Department of Pharmacy, The Third Affiliated Hospital of Soochow University, Changzhou, China *These authors contributed equally to this work Background: Evidence suggests that genetic variations of exon 1 of mannose-binding lectin 2 (MBL2) may contribute to tuberculosis (TB) risk. Many studies have investigated the association between MBL2 exon 1 polymorphisms (rs1800450, rs1800451, and rs5030737) and TB risk, but yielded inconclusive results. Method: We conducted this meta-analysis of 26 eligible case–control studies that included 7952 cases and 9328 controls to identify the strength of association. Odds ratio (OR) and 95% CI were used to evaluate the strength of association. Statistical analyses were performed by using STATA 12.1.Results: We found a statistically significant correlation between MBL2 exon 1 polymorphisms and increased TB risk among three models: allele model (O vs A: