The complex snow and glacier (cryosphere) dynamics over the "third pole" mountainous regions of the Karakoram-Hindukush-Himalayas (HKH) makes this region challenging for accurate hydrological predictions. The objective of this study is to investigate the impacts of climate change on major hydrological components (precipitation-runoff, snow- and glacier-runoff, evapotranspiration and inter-annual change in streamflows) over the Hunza-, Gilgit- and Astore-River basins, located in HKH. For this purpose, three different hydrological models (snowmelt runoff (SRM), HEC-HMS and HBV are tested over snow- and glacier-covered river basins. These are subsequently integrated with the climate projections simulated from regional climate models (RCMs) developed under CORDEX-SA experiments. The basin-wide RCM-simulations for future scenarios exhibited an increase in precipitation but decline in intensity of rise over high-altitude zones. The temperature rise showed a maximum increase during monsoon by 4.18 °C, 4.37 °C and 4.34 °C over Hunza-, Gilgit- and Astore-River basins, respectively, for the period 2071-2099 (2090s) and a high emission scenario (RCP8.5). Further, in response to rise in precipitation and temperature, the SRM simulations showed a significant increase in snow- glacier-melt runoff (49%, 42% and 46% for SRM) and precipitation runoff (23.8%, 15.7% and 27% for HEC-HMS) in the Hunza-, Gilgit- and Astore-River basins, respectively, for the 2090s under RCP8.5. The streamflow projections for SRM showed a shift in hydrological regime with an increase by 369 (168.4%), 216.5 (74.8%) and 131.8 m/s (82%) during pre-monsoon in the Hunza-, Gilgit- and Astore-River basins, respectively and then decline by -73.2 m/s (-13.9%) and -45.4 m/s (23.4%) during monsoon of the 2090s, in the Hunza- and Astore-River basins, respectively, under RCP8.5. Overall, the projections show that the pre-monsoon and monsoon seasons are expected to be strongly influenced by climate change, through alterations in snow- and glacier-accumulation, and melt regimes with substantial consequences for river runoff in the region.