This article put forward a conceptual framework of counseling and guidance for Malaysian gifted students in a school setting. The framework is derived based on various studies conducted at the national center for excellence in gifted education (also known as Pusat PERMATApintar™ Negara), instituted at Universiti Kebangsaan Malaysia since 2009. The comprehensive analysis of data sets from these on-going studies is used to develop the proposed framework which encompasses a ‘differentiated’ and ‘specialized’ approach for local population of gifted students. The framework encompasses four critical elements in ensuring the provision of effective services for the students namely, the role of counselor, the client’s personality and issues, the differentiated approaches, and the therapeutic environment. This article also discusses the implications of implementing this framework in local counseling community.