The purpose of the present study was to investigate the relationships among suicidality, substance use, self-esteem, family structure, and eight personality characteristics (harm avoidance, impulsivity, aggression, social recognition, cognitive structure, succorance, abasement, and achievement) with 337 talented, at-risk, adolescent girls. Results indicated that girls with histories of suicidal ideations and/or attempts had significantly higher levels of substance use, impulsivity, aggression, and social recognition, and significantly lower levels of self-esteem and harm avoidance than girls without such histories. Girls without suicide histories were also more likely to come from single mother families. Consideration of these factors, by both researchers and clinicians, in assessing suicide risk is encouraged.