In areas of the Cerrado-Pantanal ecotone in Brazil, the soil displays features which are inherent to the processes of soil formation, both of the Central Plateau and the Pantanal Plain. Given this premise, the area should be noteworthy for its high level of edaphic heterogeneity. The present study aimed to determine the physical, chemical and physico-hydric attributes that best explain the heterogeneity of soils in areas of the Cerrado-Pantanal ecotone, and to assess whether these attributes differ between the studied fragments and between the Cerrado soils of the Central Plateau and of the Pantanal Plain. One hundred and sixty soil samples were collected and 11 profiles described for five areas of the Cerrado-Pantanal ecotone (15º43' S, 56º04' W). The following classes were identified: typic Concretionary Petric Plinthosol; typic Lithoplintic Petric Plinthosol; typic dystrophic Yellow Latosol; dystrophic Yellow Latosol with plinthite, the last three not yet having been described for this region. The chemical attributes CEC, M, OM, K, P, Mg, Ca and Mn explained 40.49% of the variability of the soils in the region under study, whether differing or not between the studied fragments. Spatial distribution of the attributes varied between random and aggregated, with the chemical attributes CEC, K, Ca and Mg being similar to soils of the Pantanal Plain. Whereas Al, P and Mn, as well as the hydric variables, were similar to the Plateau. On the other hand, the average organic matter content, pH, gravel and pebbles, were characteristic of both the Plateau and the Plain.