Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes.
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Synthesis of Tertiary Benzylic Nitriles via Nickel-Catalyzed Markovnikov Hydrocyanation of α-Substituted Styrenes.

Xing, Yidan;Yu, Rongrong;Fang, Xianjie;
Organic letters 2020
205
xing2020synthesisorganic

Abstract

The Markovnikov hydrocyanation of α-substituted styrenes enables the synthesis of tertiary benzylic nitriles under nickel catalysis. The Lewis-acid-free transformation features an unprecedented functional groups tolerance, including the -OH and -NH groups. A broad range of tertiary benzylic nitriles were obtained in good to excellent yields. In addition, an asymmetric version of this reaction was preliminarily investigated.

Keywords

melanoma metastasis gpx4 prc2 cdr1as ezh2 igf2bp linc00632 circrna mir-7

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DOI:
10.1021/acs.orglett.9b04554

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ID: 80651
Ref Key: xing2020synthesisorganic
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