Rhodium-Catalyzed Enantioselective Anti-Markovnikov Hydroformylation of α-Substituted Acryl Acid Derivatives.
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Rhodium-Catalyzed Enantioselective Anti-Markovnikov Hydroformylation of α-Substituted Acryl Acid Derivatives.

Li, Shuailong;Li, Zhuangxing;You, Cai;Li, Xiuxiu;Yang, Jiaxin;Lv, Hui;Zhang, Xumu;
Organic letters 2020
230
li2020rhodiumcatalyzedorganic

Abstract

Rhodium-catalyzed asymmetric anti-Markovnikov hydroformylation of α-substituted acrylates/acrylamides has been developed. By employing the Rh/(,)-DTBM-YanPhos complex, a series of β-chiral linear aldehydes were obtained in high yields (up to 94% yield) and high enantioselectivities (up to 96% ee). The utility of this methodology is demonstrated by a gram-scale reaction and a concise synthetic route to chiral γ-butyrolactone.

Keywords

melanoma metastasis gpx4 prc2 cdr1as ezh2 igf2bp linc00632 circrna mir-7

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DOI:
10.1021/acs.orglett.9b04624

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ID: 80649
Ref Key: li2020rhodiumcatalyzedorganic
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