Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation.
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Diversity-oriented synthesis of spirothiazolidinediones and their biological evaluation.

Kotha, Sambasivarao;Sreevani, Gaddamedi;Dzhemileva, Lilya U;Yunusbaeva, Milyausha M;Dzhemilev, Usein M;D'yakonov, Vladimir A;
Beilstein journal of organic chemistry 2019 Vol. 15 pp. 2774-2781
235
kotha2019diversityorientedbeilstein

Abstract

We report a new synthetic approach to assemble spirothiazolidinediones via a [2 + 2 + 2] cyclotrimerization reaction and the derivatives were further functionalized through DA chemistry and click reaction. Using flow cytometry, it was shown for the first time that the new benzyl alcohol derivatives of thiazolidine-2,4-dione generated here are efficient apoptosis inducers in the HeLa, Hek293, U937, Jurkat, and K562 cell lines.

Keywords

apoptosis flow cytometry [2 + 2 + 2] cycloaddition biologically active spiro thiazolidinedione

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DOI:
10.3762/bjoc.15.269

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ID: 78126
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