The objective of this research is to identify critical success factors (CSFs) of the reusable plastic packaging (RPP) system and to establish their interrelationship in the context of manufacturing industries. Fourteen CSFs were shortlisted by reviewing the literature and considering expert team inputs. To explore the mutual influence between the identified CSFs the Interpretive Structural Modeling (ISM) approach was applied. To strengthen link interpretation, ISM methodology was supported by the Total Interpretive Structural Modeling (TISM) approach. Further, to identify the factors with high driving power the Matrice d'Impacts Croisés Multiplication Appliqués à un Classement (MICMAC) analysis was employed. It was concluded that three CSFs namely, 'top management commitment' 'lean support,' and 'optimized inventory management' were the critical ones with high influential power. This study aims to help the decision-makers in developing effective strategies for the implementation of the RPP system in the case sector for achieving sustainability.