Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals.
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Plastic Scintillator-Based Microfluidic Devices for Miniaturized Detection of Positron Emission Tomography Radiopharmaceuticals.

Tarn, Mark D;Kızılyer, Nuray Yavuzkanat;Esfahani, Mohammad M N;Joshi, Pankaj;Brown, Nathaniel J;Pamme, Nicole;Jenkins, David G;Archibald, Stephen J;
Chemistry (Weinheim an der Bergstrasse, Germany) 2018 Vol. 24 pp. 13749-13753
255
tarn2018plasticchemistry

Abstract

A miniaturized radio-HPLC detector has been developed comprising a microfluidic device fabricated from plastic scintillator in combination with a silicon photomultiplier light sensor, and tested with samples containing a positron-emitting radionuclide, [ F]fluoride. This cost-effective, small footprint analytical tool is ideal for incorporation into integrated quality control systems for the testing of positron emission tomography (PET) radiopharmaceuticals to good manufacturing practice (GMP) standards.

Keywords

positron emission tomography microfluidics liquid chromatography plastic scintillator radiopharmaceuticals silicon photomultiplier

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DOI:
10.1002/chem.201802395

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ID: 77916
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